Rapamycin相关论文
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As sessile organisms,plants must adapt to variations in the environment.Environmental stress triggers various responses,......
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新型免疫抑制剂Rapamycin具有优于环孢菌素、FK506的免疫抑制活性。它能抑制生长因子或细胞因子引起的细胞增殖。动物实验表明它对......
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Effects of Rapamycin on Clinical Manifestations and Blood Lipid Parameters in Different Preeclampsia
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Rapamycin and 3-methyladenine regulate apoptosis and autophagy in bone-derived endothelial progenito
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Mammalian target of rapamycin inhibitor abrogates abnormal osteoclastogenesis in neurofibromatosis t
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CD4~+Foxp3~+ regulatory T cells converted by rapamycin from peripheral CD4~+ CD25~-naive T cells dis
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Rapamycin attenuates bleomycin-induced pulmonary fibrosis in rats and the expression of metalloprote
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目的 探讨鞘内注射雷帕霉素对小鼠神经病理性痛行为的影响.方法 选择鞘内置管成功无运动障碍及严重体重减轻的成年雄性C57/BL6小鼠......
目的初步评估临床上应用雷帕霉素治疗激素抵抗型婴幼儿Kasabach-Merritt综合征的临床疗效及安全性。方法2015年2月至2016年4月共收......
目的探讨高氧、雷帕霉素干预后未成熟新生鼠肺组织转化生长因子β(transforming growth factor－β，TGF－β)、结缔组织生长因子(connec......
目的探讨自噬对脓毒症小鼠中性粒细胞程序性死亡配体-1（PD-L1）表达的影响及其作用机制。方法①体内实验：将6～8周龄雄性C57BL/6小鼠按随......
目的发现新的FKBP52抑制剂类药物,建立以人FKBP52为靶点的高通量药物筛选模型。方法通过大肠埃希菌表达系统重组表达FKBP52蛋白,并......
目的:探讨新型冬凌草甲素衍生物OP16和mTOR抑制剂雷帕霉素对人食管鳞癌裸鼠移植瘤生长和凋亡的影响及可能的分子机制.方法:建立人......
胃癌是世界上发病率第四高的癌症,每年胃癌会夺走700,000条生命,超过60%的胃癌由幽门螺杆菌感染引发。幽门螺杆菌的病原性有多个来......
背景和目的:在生物制药领域,蛋白类药物正处在迅猛发展时期。据Drug Bank2017年发布的最新数据表明,有5028种试验药物和4775种非冗......
目的：探讨体外联合雷帕霉素和顺铂作用于舌鳞癌细胞株后对细胞生长的影响。方法将雷帕霉素、顺铂单独（单独处理组）和联合处理（联合处理......
目的 探讨哺乳动物雷帕霉素靶蛋白(mTOR)信号通路与间变性淋巴瘤激酶(ALK)阳性淋巴瘤的关系.方法 采用Western blot法分析雷帕霉素......
目的 探讨聚乙二醇(PEG)包埋小鼠胰岛细胞对同种小鼠胰岛移植物存活的影响,以及其与抗排斥药雷帕霉素共同应用对胰岛移植后抗排斥......
引言哺乳类动物雷帕霉素靶蛋白(mammalian target of ra- pamycin,mTOR),又称雷帕霉素相关蛋白(rapamycin as- sociated protein,F......
Rapamycin, similar to FK506, can promote neural regeneration in vitro. We assumed that the mechanisms of action of rapam......
Rapamycin, similar to FK506, can promote neural regeneration in vitro. We assumed that the mechanisms of action of rapam......
延年益寿是所有人的追求，现在生物医学研究为延年益寿提供了一些实际可行的方案：一是改变基因，二是改变生活方式，三是服用药物。但是，现......
目的:难治性获得性血友病A(AHA)对激素与常用的免疫抑制剂无反应,出血危险性大,我们试用雷帕霉素治疗1例难治性AHA患者。方法:用全......
Objective: To investigate the effect of rapamycin on cognitive function of Operative Cognitive Dysfunction rats induced ......
目的评估本实验室自制包载雷帕霉素(RPM)的聚乳酸-聚乙醇酸共聚物(PLGA)纳米粒子(NPs)对离体培养的人脐动脉平滑肌细胞(HUASMC)细......
目的探讨自噬诱导剂雷帕霉素和自噬抑制剂3-甲基腺嘌呤(3-MA)对C57BL/6帕金森病(PD)模型小鼠运动行为及自噬相关蛋白LC3的影响。方......
Differential regulation of protein synthesis in skeletal muscle and liver of neonatal pigs by leucin
Neonatal growth is characterized by a high protein synthesis rate that is largely due to an enhanced sensitivity to the ......
目的探讨自噬诱导剂雷帕霉素对脓毒症急性肾损伤（AKI）的保护作用。方法将24只雄性SD大鼠按随机数字表法分为假手术（Sham）组、盲肠结扎......
目的评价雷帕霉素联合碘-125(I125)治疗中晚期非小细胞肺癌(NSCLC)的临床疗效。方法 92例NSCLC患者随机分为对照组和试验组,每组46......
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哺乳动物雷帕霉素靶蛋白(mTOR)是一种高度进化保守的蛋白激酶,控制细胞生长、生长因子和细胞能量的形成,参与营养、新陈代谢及老化......
该文从挂篮荷载计算、施工流程、支座及临时固结施工、挂篮安装及试验、合拢段施工、模板制作安装、钢筋安装、混凝土的浇筑及养生......
目的探讨雷帕霉素对刀豆蛋白A（ConA）诱导的自身免疫性肝炎及纤维化进展的防治作用，并探讨其机制。方法8周龄雌性C57BL/6小鼠随机分为......
目的探讨油酸及软脂酸对HepG2细胞脂质沉积及雷帕霉素靶蛋白（mTOR）/蛋白核糖体S6蛋白激酶1（S6K1）/固醇调节元件结合蛋白1c（SREBP-1c）通路......
Rapamycin instead of mycophenolate mofetil or azathioprine in treatment of post-renal transplantatio
Background Malignant tumor is the most common complication occurred in transplant recipients. It is widely recognized th......
CD4~+Foxp3~+ regulatory T cells converted by rapamycin from peripheral CD4~+ CD25~-naive T cells dis
Background Rapamycin (RAPA) is a relatively new immunosuppressant drug that functions as a serine/threonine kinase inhib......
Inactivation of mammalian target of rapamycin (mTOR) by rapamycin in a murine model of lipopolysacch
Background The mammalian target of rapamycin (mTOR) pathway, a key cellular signaling pathway associated with various ce......
Rapamycin and 3-methyladenine regulate apoptosis and autophagy in bone-derived endothelial progenito
Background Mammalian target of rapamycin(mTOR)is involved in a caspase independent form of programmed cell death called ......
Background Stent thrombosis is one of severe complications after sirolimus-eluting stent implantation.Rapamycin (sirolim......
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Mammalian target of rapamycin inhibitor abrogates abnormal osteoclastogenesis in neurofibromatosis t
Background Neurofibromatosis type 1 (NF1) is the most common genetic syndrome predisposing patients to various tumors du......
Rapamycin attenuates bleomycin-induced pulmonary fibrosis in rats and the expression of metalloprote
Background Idiopathic pulmonary fibrosis (IPF) is the most common and devastating form of interstitial lung disease (ILD......
